Odds, tips and predictions for the game Houston Astros vs San Diego Padres

The Houston Astros (82-69) and San Diego Padres (86-66) meet on Wednesday for the finale of a 3-game series. First pitch from Petco Park is scheduled for 6:40 p.m. ET. Let's check out BetMGM Sportsbook's MLB odds around the Astros vs Padres Opportunities and place your best bets with our expert MLB tips and predictions.

Season series: 1:1 draw

Houston came away with a 4-3 win in 10 innings against San Diego on Tuesday as a +108 underdog. After 2B Jose Altuve was thrown out in the 9th inning for taking off his shoe – he claimed he fouled a ball off his foot – his replacement Grae Kessinger scored an RBI single from RF in the 10th inning to take the lead Kyle Tucker.

The loss ended a four-game winning streak for the Padres. San Diego and Houston are virtually guaranteed playoff contenders at this point; their chances of making the playoffs are 99.5 and 98.9 percent, respectively, according to FanGraphs.com.

Expected Astros starters at the Padres

LHP Framber Valdez against RHP Dylan Cease

Valdez (14-6, 2.91 ERA) is making his 27th start. He has a WHIP of 1.09, 2.8 BB/9 and 8.7 K/9 in 163 2/3 innings.

• Last start: No decision, 6 1/3 IP, 1 ER, 5 H, 1 BB, 6 K in the 6-3 home win against Oakland A's on Thursday
• Career vs. San Diego: 0-1, 4.50 ERA (10 IP, 5 ER), 1.20 WHIP, 7.2 K/9 in 2 starts in 2021

Cease (13-11, 3.58 ERA) is making his 32nd start. He has a WHIP of 1.09, 3.2 BB/9 and 11.0 K/9 in 176 innings.

• Last start: Win, 6 IP, 0 ER, 4 H, 2 BB, 10 K in the 5-0 win at the San Francisco Giants on Friday
• Career vs. Houston (regular season): 0-3, 4.18 ERA (32 1/3 IP, 15 ER), 1.27 WHIP, 9.7 K/9 in 6 starts, including 0-0 with 0.73 ERA (12 1/3 IP, 1 ER) in 2 starts last year

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Astros vs Padres odds

Provided by BetMGM Sportsbook; visit the USA TODAY Sports Scores and Sports Betting Odds Hub for a complete list of MLB odds. Odds last updated at 9:45 a.m. ET on Wednesday.

• Moneyline (ML): Astros -115 (bet $115 to win $100) | Padres -105 (bet $105 to win $100)
• Running Line (RL)/Against the Spread (ATS): Astros -1.5 (+155) | Padres +1.5 (-190)
• Over/Under (O/U): 7 (O: -120 | U: +100)

Tips and predictions for the Astros at the Padres

forecast

Astros 3, Padres 2

Money line

SLEEK HOUSTON (-115).

Houston are 4-1 in their last 5 road games and 5-1 in their last 6 overall, while the Padres are just 1-3 in their last 4 home games. The Astros are also 3-1 in the last 4 meetings between these teams.

This is more of a trend, as these are two very evenly matched teams and the Padres are 3-2 in their last five meetings in San Diego.

Running Line/Against the Spread

HAPPEN.

This should be a close matchup, as both teams are 6-4 in their last 10 games overall and the last 10 meetings have ended 5-5. As such, I expect the Padres to be +1.5 (-190) underdogs here. However, that line is too cheap to risk a bet, so bet on the ML and/or total instead.

Over/Under

BET UNDER 7 (+100).

Overall, the under has scored in each of San Diego's last 3 games and has a record of 3-2 in their last 5 home games.

Note that the over in the last 10 matches is 6-3-1.

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